Midway through a classic episode of Seinfeld, Jerry intentionally bombs a stand-up routine by asking the crowd, “What’s the deal with cancer?” His tasteless bit is a reminder that comedy and fatal disease are uneasy bedfellows. Jonathan Levine’s 50/50, a comedy about a young man with cancer, understands this tension well. It never makes light of cancer, instead using warmth to consider how humor is critical to how the man copes. There are moments where laughter offers needed relief, and others where it is outright courageous. With seemingly effortless power, this is the rare dramedy that earns every chuckle and tear it strives for.